Revenue Recognition - Disaggregation of Revenue (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2020	Mar. 31, 2019
Disaggregation of Revenue [Line Items]
Revenues	$ 1,515,107	$ 858,435
United States
Disaggregation of Revenue [Line Items]
Revenues	1,187,588	641,104
Europe
Disaggregation of Revenue [Line Items]
Revenues	257,391	167,751
Other
Disaggregation of Revenue [Line Items]
Revenues	70,128	49,580
Total revenues outside of the United States
Disaggregation of Revenue [Line Items]
Revenues	327,519	217,331
Product revenues, net
Disaggregation of Revenue [Line Items]
Revenues	1,515,107	857,253
TRIKAFTA
Disaggregation of Revenue [Line Items]
Revenues	895,233	0
SYMDEKO/SYMKEVI
Disaggregation of Revenue [Line Items]
Revenues	173,159	320,275
ORKAMBI
Disaggregation of Revenue [Line Items]
Revenues	234,138	293,007
KALYDECO
Disaggregation of Revenue [Line Items]
Revenues	$ 212,577	$ 243,971