Additional Balance Sheet Detail (Details) - USD ($) $ in Thousands	Dec. 31, 2019	Jan. 01, 2019	Dec. 31, 2018
Accrued expenses
Payroll and benefits	$ 159,464		$ 124,753
Research, development and commercial contract costs	105,663		115,300
Product revenue allowances	641,368		550,002
Royalty payable	98,578		101,108
Tax related accruals	72,293		43,281
Other	39,546		24,455
Total	1,116,912		958,899
Other current liabilities
Contract liabilities	62,332		24,870
Finance lease liabilities	30,293
Capital lease obligations			5,271
Other	37,680		20,265
Total	130,305		50,406
Other long-term liabilities
Advance from collaborator	88,762		82,573
Operating lease liabilities	84,292
Other	10,264		26,280
Total	$ 183,318	$ 70,226	$ 108,853