- Cash Flow Hedging Instruments (Details) - USD ($) $ in Thousands	3 Months Ended								12 Months Ended
	Dec. 31, 2019	Sep. 30, 2019	Jun. 30, 2019	Mar. 31, 2019	Dec. 31, 2018	Sep. 30, 2018	Jun. 30, 2018	Mar. 31, 2018	Dec. 31, 2019	Dec. 31, 2018	Dec. 31, 2017
Derivative Instruments, Gain (Loss) [Line Items]
Product revenues, net	$ 1,413,265	$ 949,828	$ 941,293	$ 858,435	$ 870,106	$ 784,535	$ 752,157	$ 640,799	$ 4,162,821	$ 3,047,597	$ 2,488,652
Other income (expense), net	127,375	(31,747)	53,939	42,610	(90,452)	(60,995)	53,819	96,838	192,177	(790)	(81,382)
Foreign currency forward contracts | Product revenues, net | Designated as hedging instruments
Derivative Instruments, Gain (Loss) [Line Items]
Gain (loss) on derivatives designated as hedging instruments									32,546
Gain (loss) on cash flow hedging instruments										(1,252)	768
Foreign currency forward contracts | Other (expense) income, net
Derivative Instruments, Gain (Loss) [Line Items]
Gain (loss) on derivatives not designated as hedging instruments									4,838
Foreign currency forward contracts | Other (expense) income, net | Not designated as hedging instrument
Derivative Instruments, Gain (Loss) [Line Items]
Gain (loss) on cash flow hedging instruments										623	14,129
Product
Derivative Instruments, Gain (Loss) [Line Items]
Product revenues, net	$ 1,413,265	$ 949,828	$ 940,380	$ 857,253	$ 868,173	$ 782,511	$ 749,912	$ 637,729	$ 4,160,726	$ 3,038,325	$ 2,165,480