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Collaborative Arrangements - BioAxone Biosciences, Inc. (Details) - USD ($)
$ in Thousands
1 Months Ended 3 Months Ended 12 Months Ended
Dec. 31, 2018
Dec. 31, 2018
Sep. 30, 2018
Jun. 30, 2018
Mar. 31, 2018
Dec. 31, 2019
Dec. 31, 2018
Dec. 31, 2017
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                
Intangible asset impairment charges   $ 29,000 $ 0 $ 0 $ 0 $ 0 $ 29,000 $ 255,340
Variable Interest Entity, Primary Beneficiary | Other Intangible Assets | BioAxone Biosciences, Inc                
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                
Intangible asset impairment charges $ 29,000           $ 29,000 $ 29,000