Collaborative Arrangements - Parion Sciences, Inc. (Details) - USD ($)	1 Months Ended	3 Months Ended									12 Months Ended
	Dec. 31, 2018	Dec. 31, 2019	Sep. 30, 2019	Jun. 30, 2019	Mar. 31, 2019	Dec. 31, 2018	Sep. 30, 2018	Jun. 30, 2018	Mar. 31, 2018	Sep. 30, 2017	Dec. 31, 2019	Dec. 31, 2018	Dec. 31, 2017
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Provision for (benefit from) income taxes		$ 93,716,000	$ 13,148,000	$ 59,711,000	$ 51,534,000	$ (1,492,599,000)	$ 8,055,000	$ 10,341,000	$ (12,659,000)		$ 218,109,000	$ (1,486,862,000)	$ (107,324,000)
Intangible asset impairment charges						$ 29,000,000	$ 0	$ 0	$ 0		0	29,000,000	255,340,000
(Increase) decrease in fair value of contingent payments		$ (1,500,000)	$ (2,959,000)	$ 0	$ 0						$ (4,459,000)	0	0
Parion Sciences, Inc
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Provision for (benefit from) income taxes										$ (126,200,000)
(Increase) decrease in fair value of contingent payments										69,600,000
Income tax expense (benefit), attributable to intangible asset impairment										(97,700,000)
Income tax expense (benefit), attributable to decrease in the fair value of contingent consideration liability										(28,500,000)
Deconsolidation,loss, amount													7,100,000
Variable Interest Entity, Primary Beneficiary
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Provision for (benefit from) income taxes												(3,668,000)	(114,090,000)
(Increase) decrease in fair value of contingent payments												(17,730,000)	62,560,000
Variable Interest Entity, Primary Beneficiary | Parion Sciences, Inc
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Collaborative and royalty revenues													40,000,000.0
Provision for (benefit from) income taxes													14,800,000
Fair value of intangible asset										255,300,000
Other Intangible Assets | Variable Interest Entity, Primary Beneficiary | Parion Sciences, Inc
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Intangible asset impairment charges										255,300,000			255,300,000
Fair value of intangible asset										$ 0
Other Intangible Assets | Variable Interest Entity, Primary Beneficiary | BioAxone Biosciences, Inc
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Intangible asset impairment charges	$ 29,000,000.0											$ 29,000,000.0	$ 29,000,000