Condensed Consolidated Balance Sheets - USD ($) $ in Thousands	Sep. 30, 2019	Dec. 31, 2018
Current assets:
Cash and cash equivalents	$ 3,397,941	$ 2,650,134
Marketable securities	598,390	518,108
Accounts receivable, net	443,315	409,688
Inventories	162,306	124,360
Prepaid expenses and other current assets	175,142	140,819
Total current assets	4,777,094	3,843,109
Property and equipment, net	733,509	812,005
Goodwill	447,525	50,384
Deferred tax assets	1,415,511	1,499,672
Operating lease assets	60,929
Other assets	79,985	40,728
Total assets	7,514,553	6,245,898
Current liabilities:
Accounts payable	92,528	110,987
Accrued expenses	1,173,783	958,899
Other current liabilities	122,583	50,406
Total current liabilities	1,388,894	1,120,292
Long-term finance lease liabilities	541,561
Long-term finance lease liabilities		581,550
Long-term operating lease liabilities	62,978
Long-term advance from collaborator	85,084	82,573
Long-term contingent consideration	175,000	0
Other long-term liabilities	7,642	26,280
Total liabilities	2,261,159	1,810,695
Commitments and contingencies	0	0
Shareholders’ equity:
Preferred stock, $0.01 par value; 1,000 shares authorized; none issued and outstanding	0	0
Common stock, $0.01 par value; 500,000 shares authorized, 257,265 and 255,172 shares issued and outstanding, respectively	2,571	2,546
Additional paid-in capital	7,668,188	7,421,476
Accumulated other comprehensive income	18,847	659
Accumulated deficit	(2,436,212)	(2,989,478)
Total shareholders’ equity	5,253,394	4,435,203
Total liabilities and shareholders’ equity	$ 7,514,553	$ 6,245,898