Condensed Consolidated Balance Sheets - USD ($) $ in Thousands	Jun. 30, 2019	Dec. 31, 2018
Current assets:
Cash and cash equivalents	$ 3,294,684	$ 2,650,134
Marketable securities	656,538	518,108
Accounts receivable, net	464,900	409,688
Inventories	143,017	124,360
Prepaid expenses and other current assets	151,829	140,819
Total current assets	4,710,968	3,843,109
Property and equipment, net	731,131	812,005
Goodwill	50,384	50,384
Deferred tax assets	1,425,191	1,499,672
Operating lease assets	58,031
Other assets	57,766	40,728
Total assets	7,033,471	6,245,898
Current liabilities:
Accounts payable	77,045	110,987
Accrued expenses	1,069,072	958,899
Other current liabilities	113,103	50,406
Total current liabilities	1,259,220	1,120,292
Long-term finance lease liabilities	551,530
Long-term finance lease liabilities		581,550
Long-term operating lease liabilities	60,433
Long-term advance from collaborator	84,309	82,573
Other long-term liabilities	8,014	26,280
Total liabilities	1,963,506	1,810,695
Commitments and contingencies	0	0
Shareholders’ equity:
Preferred stock, $0.01 par value; 1,000 shares authorized; none issued and outstanding	0	0
Common stock, $0.01 par value; 500,000 shares authorized, 256,671 and 255,172 shares issued and outstanding, respectively	2,565	2,546
Additional paid-in capital	7,564,331	7,421,476
Accumulated other comprehensive (loss) income	(3,201)	659
Accumulated deficit	(2,493,730)	(2,989,478)
Total shareholders’ equity	5,069,965	4,435,203
Total liabilities and shareholders’ equity	$ 7,033,471	$ 6,245,898