Condensed Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2019	Jun. 30, 2018	Jun. 30, 2019	Jun. 30, 2018
Revenues:
Revenues	$ 941,293	$ 752,157	$ 1,799,728	$ 1,392,956
Costs and expenses:
Cost of sales	135,740	104,382	230,832	175,995
Research and development expenses	379,091	337,532	718,581	648,085
Sales, general and administrative expenses	156,502	137,303	303,547	267,111
Restructuring expense (income)	0	62	0	(14)
Total costs and expenses	671,333	579,279	1,252,960	1,091,177
Income from operations	269,960	172,878	546,768	301,779
Interest income	18,076	8,049	33,691	13,838
Interest expense	(14,837)	(18,155)	(29,705)	(35,041)
Other income, net	53,939	53,819	96,549	150,657
Income before provision for (benefit from) income taxes	327,138	216,591	647,303	431,233
Provision for (benefit from) income taxes	59,711	10,341	111,245	(2,318)
Net income	267,427	206,250	536,058	433,551
Loss (income) attributable to noncontrolling interest	0	1,110	0	(15,928)
Net income attributable to Vertex	$ 267,427	$ 207,360	$ 536,058	$ 417,623
Net income:
Basic (in dollars per share)	$ 1.04	$ 0.82	$ 2.09	$ 1.65
Diluted (in dollars per share)	$ 1.03	$ 0.80	$ 2.06	$ 1.61
Shares used in per share calculations:
Basic (in shares)	256,154	254,135	255,941	253,685
Diluted (in shares)	259,822	258,584	260,015	258,557
Product revenues, net
Revenues:
Revenues	$ 940,380	$ 749,912	$ 1,797,633	$ 1,387,641
Collaborative and royalty revenues
Revenues:
Revenues	$ 913	$ 2,245	$ 2,095	$ 5,315