Revenue Recognition (Tables)

3 Months Ended

Mar. 31, 2019

Revenue from Contract with Customer [Abstract]

Schedule of disaggregation of revenue

Product revenues, net consisted of the following:

	Three Months Ended March 31,
	2019		2018
	(in thousands)
SYMDEKO/SYMKEVI	$	320,275	$	34,124
ORKAMBI	293,007		354,066
KALYDECO	243,971		249,539
Total product revenues, net	$	857,253	$	637,729

Total revenues from external customers and collaborators by geographic region consisted of the following:

	Three Months Ended March 31,
	2019		2018
	(in thousands)
United States	$	641,104	$	482,667
Outside of the United States
Europe	167,751		131,895
Other	49,580		26,237
Total revenues outside of the United States	217,331		158,132
Total revenues	$	858,435	$	640,799