<SEC-DOCUMENT>0000875320-19-000007-index.html : 20190213
<SEC-HEADER>0000875320-19-000007.hdr.sgml : 20190213
<ACCEPTANCE-DATETIME>20190213164418
ACCESSION NUMBER:		0000875320-19-000007
CONFORMED SUBMISSION TYPE:	S-3ASR
PUBLIC DOCUMENT COUNT:		4
FILED AS OF DATE:		20190213
DATE AS OF CHANGE:		20190213
EFFECTIVENESS DATE:		20190213

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			VERTEX PHARMACEUTICALS INC / MA
		CENTRAL INDEX KEY:			0000875320
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				043039129
		STATE OF INCORPORATION:			MA
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		S-3ASR
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-229656
		FILM NUMBER:		19598115

	BUSINESS ADDRESS:	
		STREET 1:		50 NORTHERN AVENUE
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02210
		BUSINESS PHONE:		6173416393

	MAIL ADDRESS:	
		STREET 1:		50 NORTHERN AVENUE
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02210
</SEC-HEADER>
<DOCUMENT>
<TYPE>S-3ASR
<SEQUENCE>1
<FILENAME>s-32019.htm
<DESCRIPTION>S-3ASR
<TEXT>
Document 1 - file: s-32019.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>2
<FILENAME>vrtx_-xexhibitx5x1xopinion.htm
<DESCRIPTION>EXHIBIT 5.1
<TEXT>
Document 2 - file: vrtx_-xexhibitx5x1xopinion.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.1
<SEQUENCE>3
<FILENAME>exhibit_231xs-3x2019.htm
<DESCRIPTION>EXHIBIT 23.1
<TEXT>
Document 3 - file: exhibit_231xs-3x2019.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>4
<FILENAME>image03a05.jpg
<TEXT>
Document 4 - file: image03a05.jpg

</DOCUMENT>
</SEC-DOCUMENT>