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Stock-based Compensation Expense (Details) - USD ($)
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Stock-based compensation expense:      
Stock-based compensation expense $ 325,047,000 $ 293,236,000 $ 240,623,000
Stock-based compensation expense related to inventories (585,000) (2,406,000) (689,000)
Allocated stock-based compensation expense 325,047,000 $ 293,236,000 $ 240,623,000
Stock Options      
Weighted-average assumptions for options and ESPP subscriptions granted      
Expected annual dividends $ 0    
Employee stock purchase plan      
Weighted-average assumptions for options and ESPP subscriptions granted      
Expected stock price volatility (percent) 36.51% 39.09% 48.22%
Risk-free interest rate (percent) 2.36% 1.24% 0.56%
Expected term of options (in years) 9 months 9 months 9 months
Expected annual dividends $ 0 $ 0 $ 0
Weighted average fair value (usd per share) $ 44.04 $ 35.90 $ 26.86
Tranche one      
Weighted-average assumptions for options and ESPP subscriptions granted      
Vesting rights percentage 33.30%    
Tranche two      
Weighted-average assumptions for options and ESPP subscriptions granted      
Vesting rights percentage 33.30%    
Tranche three      
Weighted-average assumptions for options and ESPP subscriptions granted      
Vesting rights percentage 33.30%    
Performance-based RSUs      
Weighted-average assumptions for options and ESPP subscriptions granted      
Potential awards, percent of target shares, minimum 0.00%    
Potential awards, percent of target shares, maximum 200.00%    
Weighted average fair value (usd per share) $ 152.40    
Performance-based RSUs | Tranche one      
Weighted-average assumptions for options and ESPP subscriptions granted      
Vesting period 3 years    
Performance-based RSUs | Tranche two      
Weighted-average assumptions for options and ESPP subscriptions granted      
Vesting period 3 years    
Financial performance shares      
Weighted-average assumptions for options and ESPP subscriptions granted      
Vesting period 3 years    
Non-financial performance shares      
Weighted-average assumptions for options and ESPP subscriptions granted      
Vesting period 3 years    
Stock options      
Stock-based compensation expense:      
Stock-based compensation expense $ 107,854,000 $ 105,367,000 $ 114,768,000
Type of award:      
Unrecognized Expense $ 155,465,000    
Weighted-average Recognition Period 2 years 7 months 21 days    
Weighted-average grant-date fair value, granted (usd per share) $ 60.83 $ 43.27 $ 37.93
Weighted-average assumptions for options and ESPP subscriptions granted      
Expected stock price volatility (percent) 40.50% 45.31% 46.77%
Risk-free interest rate (percent) 2.61% 1.94% 1.32%
Expected term of options (in years) 4 years 6 months 18 days 4 years 8 months 5 days 4 years 10 months 28 days
Expected annual dividends $ 0 $ 0 $ 0
Restricted stock and restricted stock units (including PSUs)      
Stock-based compensation expense:      
Stock-based compensation expense 207,845,000 181,258,000 118,709,000
Type of award:      
Unrecognized Expense $ 321,683,000    
Weighted-average Recognition Period 2 years 6 months 29 days    
ESPP share issuances      
Stock-based compensation expense:      
Stock-based compensation expense $ 9,933,000 9,017,000 7,835,000
Type of award:      
Unrecognized Expense $ 5,132,000    
Weighted-average Recognition Period 6 months 29 days    
Cost of sales      
Stock-based compensation expense:      
Stock-based compensation expense $ 4,543,000 2,500,000 2,918,000
Research and development expenses      
Stock-based compensation expense:      
Stock-based compensation expense 203,112,000 181,900,000 153,451,000
Sales, general and administrative expenses      
Stock-based compensation expense:      
Stock-based compensation expense $ 117,392,000 $ 108,836,000 $ 84,254,000