Additional Balance Sheet Detail (Details) - USD ($) $ in Thousands	Dec. 31, 2018	Jan. 01, 2018	Dec. 31, 2017
Prepaid and other current assets
Prepaid expenses	$ 74,045		$ 62,475
Collaborative accounts receivable	5,182		28,907
Other receivables and assets	61,592		75,742
Total	140,819	$ 149,958	167,124
Accrued expenses
Payroll and benefits	124,753		113,026
Research, development and commercial contract costs	115,300		98,411
Product revenue allowances	195,598		119,919
Royalty payable	101,108		73,044
Other	67,736		39,561
Total	$ 604,495	$ 452,547	$ 443,961