Intangible Assets and Goodwill (Details) - USD ($)	3 Months Ended								12 Months Ended
	Dec. 31, 2018	Sep. 30, 2018	Jun. 30, 2018	Mar. 31, 2018	Dec. 31, 2017	Sep. 30, 2017	Jun. 30, 2017	Mar. 31, 2017	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
Indefinite-Lived Intangible Assets [Line Items]
Intangible assets	$ 0				$ 29,000,000				$ 0	$ 29,000,000
Intangible asset impairment charges	29,000,000	$ 0	$ 0	$ 0	0	$ 255,340,000	$ 0	$ 0	29,000,000	255,340,000	$ 0
(Benefit from) provision for income taxes	(1,492,599,000)	$ 8,055,000	$ 10,341,000	$ (12,659,000)	10,257,000	(125,903,000)	$ 4,337,000	$ 3,985,000	(1,486,862,000)	(107,324,000)	16,665,000
Goodwill	$ 50,384,000				$ 50,384,000				50,384,000	50,384,000
Parion Sciences, Inc
Indefinite-Lived Intangible Assets [Line Items]
Intangible asset impairment charges						255,300,000
(Benefit from) provision for income taxes						(126,200,000)
Variable Interest Entity, Primary Beneficiary
Indefinite-Lived Intangible Assets [Line Items]
(Benefit from) provision for income taxes									(3,668,000)	(114,090,000)	16,743,000
Variable Interest Entity, Primary Beneficiary | Parion Sciences, Inc
Indefinite-Lived Intangible Assets [Line Items]
Intangible assets											$ 255,300,000
Fair value of intangible asset						0
(Benefit from) provision for income taxes										14,800,000
Other Intangible Assets | Variable Interest Entity, Primary Beneficiary | Parion Sciences, Inc
Indefinite-Lived Intangible Assets [Line Items]
Intangible asset impairment charges						255,300,000				255,300,000
(Benefit from) provision for income taxes										$ (97,700,000)
Other Intangible Assets | Variable Interest Entity, Primary Beneficiary | BioAxone Biosciences, Inc
Indefinite-Lived Intangible Assets [Line Items]
Intangible asset impairment charges						$ 29,000,000
(Benefit from) provision for income taxes									$ (7,900,000)