Consolidated Balance Sheets - USD ($) $ in Thousands	Dec. 31, 2018	Dec. 31, 2017
Current assets:
Cash and cash equivalents	$ 2,650,134	$ 1,665,412
Marketable securities	518,108	423,254
Accounts receivable, net	409,688	281,343
Inventories	124,360	111,830
Prepaid expenses and other current assets	140,819	167,124
Total current assets	3,843,109	2,648,963
Property and equipment, net	812,005	789,437
Intangible assets	0	29,000
Goodwill	50,384	50,384
Deferred tax assets	1,499,672	834
Other assets	40,728	27,396
Total assets	6,245,898	3,546,014
Current liabilities:
Accounts payable	110,987	73,994
Accrued expenses	604,495	443,961
Capital lease obligations, current portion	9,817	22,531
Early access sales accrual	354,404	232,401
Other liabilities, current portion	40,589	34,373
Total current liabilities	1,120,292	807,260
Capital lease obligations, excluding current portion	19,658	20,496
Deferred tax liabilities	0	6,341
Construction financing lease obligation, excluding current portion	561,892	563,406
Advance from collaborator, excluding current portion	82,573	78,431
Other liabilities, excluding current portion	26,280	27,774
Total liabilities	1,810,695	1,503,708
Commitments and contingencies	0	0
Shareholders’ equity:
Preferred stock, $0.01 par value; 1,000,000 shares authorized; none issued and outstanding	0	0
Common stock, $0.01 par value; 500,000,000 shares authorized, 255,172,328 and 253,253,362 shares issued and outstanding, respectively	2,546	2,512
Additional paid-in capital	7,421,476	7,157,362
Accumulated other comprehensive income (loss)	659	(11,572)
Accumulated deficit	(2,989,478)	(5,119,723)
Total Vertex shareholders’ equity	4,435,203	2,028,579
Noncontrolling interest	0	13,727
Total shareholders’ equity	4,435,203	2,042,306
Total liabilities and shareholders’ equity	$ 6,245,898	$ 3,546,014