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Stock-based Compensation Expense (Tables)
12 Months Ended
Dec. 31, 2018
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]  
Stock-based compensation expense by line item
The effect of stock-based compensation expense during the three years ended December 31, 2018 was as follows:
 
2018
 
2017
 
2016
 
(in thousands)
Stock-based compensation expense by line item:
 
 
 
 
 
Cost of sales
$
4,543

 
$
2,500

 
$
2,918

Research and development expenses
203,112

 
181,900

 
153,451

Sales, general and administrative expenses
117,392

 
108,836

 
84,254

Total stock-based compensation expense included in costs and expenses
$
325,047

 
$
293,236

 
$
240,623

Stock-based compensation expense by type of award
The stock-based compensation expense by type of award during the three years ended December 31, 2018 was as follows:
 
2018
 
2017
 
2016
 
(in thousands)
Stock-based compensation expense by type of award:
 
 
 
 
 
Stock options
$
107,854

 
$
105,367

 
$
114,768

Restricted stock and restricted stock units (including PSUs)
207,845

 
181,258

 
118,709

ESPP share issuances
9,933

 
9,017

 
7,835

Stock-based compensation expense related to inventories
(585
)
 
(2,406
)
 
(689
)
Total stock-based compensation expense included in costs and expenses
$
325,047

 
$
293,236

 
$
240,623

Unrecognized stock-based compensation expense, net of estimated forfeitures
The following table sets forth the Company’s unrecognized stock-based compensation expense as of December 31, 2018, by type of award and the weighted-average period over which that expense is expected to be recognized:
 
As of December 31, 2018
 
Unrecognized Expense
 
Weighted-average Recognition Period
 
(in thousands)
 
(in years)
Type of award:
 
 
 
Stock options
$
155,465

 
2.64
Restricted stock and restricted stock units (including PSUs)
$
321,683

 
2.58
ESPP share issuances
$
5,132

 
0.58
Schedule of assumptions used to estimate the grant date fair value of options
The fair value of each option granted during 2018, 2017 and 2016 was estimated on the date of grant using the Black-Scholes option pricing model with the following weighted-average assumptions:
 
2018
 
2017
 
2016
Expected stock price volatility
40.50
%
 
45.31
%
 
46.77
%
Risk-free interest rate
2.61
%
 
1.94
%
 
1.32
%
Expected term of options (in years)
4.55

 
4.68

 
4.91

Expected annual dividends

 

 

Schedule of assumptions used to estimate the grant date fair value employee stock purchase plan
The following table reflects the weighted-average assumptions used in the Black-Scholes option pricing model for 2018, 2017 and 2016:
 
2018
 
2017
 
2016
Expected stock price volatility
36.51
%
 
39.09
%
 
48.22
%
Risk-free interest rate
2.36
%
 
1.24
%
 
0.56
%
Expected term (in years)
0.75

 
0.75

 
0.75

Expected annual dividends