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Collaborative Arrangements (Tables)
 12 Months Ended
Dec. 31, 2018
Organization, Consolidation and Presentation of Financial Statements [Abstract]  
Schedule of collaborative arrangement activity net loss attributable to noncontrolling interest
An aggregate summary of net loss attributable to noncontrolling interest related to the Company’s VIEs for the three years ended December 31, 2018 was as follows:
 
2018
 
2017
 
2016
 
(in thousands)
Loss attributable to noncontrolling interest before (benefit from) provision for income taxes and changes in fair value of contingent payments
$
31,191

 
$
223,379

 
$
10,086

(Benefit from) provision for income taxes
(3,668
)
 
(114,090
)
 
16,743

(Increase) decrease in fair value of contingent payments
(17,730
)
 
62,560

 
(54,850
)
Net loss (income) attributable to noncontrolling interest
$
9,793

 
$
171,849

 
$
(28,021
)
Schedule of changes in fair value of contingent payments
During three years ended December 31, 2018, the (increases) decreases in the fair value of the contingent payments related to the Company’s VIEs were as follows:
 
2018
 
2017
 
2016
 
(in thousands)
Parion
$
—

 
$
63,460

 
$
(64,800
)
BioAxone
(17,730
)
 
(900
)
 
9,950
Schedule of collaborative arrangement summary of items related to variable interest entities
As of December 31, 2018, the Company did not have any consolidated VIEs. As of December 31, 2017, the Company’s consolidated balance sheet included the following significant amounts related to its consolidation of BioAxone as a VIE:
 
December 31, 2017
 
(in thousands)
Intangible assets
$
29,000

Deferred tax liabilities
4,756

Noncontrolling interest
13,727