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Marketable Securities and Equity Investments - Marketable securities and equity investments (Details) - USD ($)
3 Months Ended 9 Months Ended
Sep. 30, 2018
Sep. 30, 2017
Sep. 30, 2018
Sep. 30, 2017
Summary of cash equivalents and marketable securities        
Other than temporary impairment losses, investments   $ 0 $ 0  
Gross realized gains (losses) $ 0 $ 0    
Unrealized gain (loss) on investments 61,200,000   (88,200,000)  
Payments to Acquire Investments     60,490,000 $ 0
CRISPR        
Summary of cash equivalents and marketable securities        
Unrealized gain (loss) on investments 61,200,000   (85,300,000)  
Payments to Acquire Investments     46,900,000  
Investments in privately held companies        
Summary of cash equivalents and marketable securities        
Unrealized gain (loss) on investments 0   (2,900,000)  
Other assets        
Summary of cash equivalents and marketable securities        
Carrying value of investments 36,700,000   36,700,000  
Corporate equity securities | CRISPR        
Summary of cash equivalents and marketable securities        
Fair value of equity investment $ 207,036,000   $ 207,036,000