Condensed Consolidated Balance Sheets - USD ($) $ in Thousands	Sep. 30, 2018	Dec. 31, 2017
Current assets:
Cash and cash equivalents	$ 2,478,302	$ 1,665,412
Marketable securities	577,583	423,254
Restricted cash and cash equivalents (VIE)	8,143	1,489
Accounts receivable, net	379,755	281,343
Inventories	124,150	111,830
Prepaid expenses and other current assets	118,678	165,635
Total current assets	3,686,611	2,648,963
Property and equipment, net	808,352	789,437
Intangible assets	29,000	29,000
Goodwill	50,384	50,384
Other assets	46,493	28,230
Total assets	4,620,840	3,546,014
Current liabilities:
Accounts payable	92,149	73,994
Accrued expenses	504,240	443,961
Capital lease obligations, current portion	11,511	22,531
Early access sales accrual	324,251	232,401
Other liabilities, current portion	60,357	34,373
Total current liabilities	992,508	807,260
Capital lease obligations, excluding current portion	15,141	20,496
Deferred tax liability	9,414	6,341
Construction financing lease obligation, excluding current portion	561,389	563,406
Advance from collaborator, excluding current portion	81,610	78,431
Other liabilities, excluding current portion	26,297	27,774
Total liabilities	1,686,359	1,503,708
Commitments and contingencies
Shareholders’ equity:
Preferred stock, $0.01 par value; 1,000,000 shares authorized; none issued and outstanding	0	0
Common stock, $0.01 par value; 500,000,000 shares authorized, 255,610,812 and 253,253,362 shares issued and outstanding, respectively	2,551	2,512
Additional paid-in capital	7,443,263	7,157,362
Accumulated other comprehensive income (loss)	307	(11,572)
Accumulated deficit	(4,540,005)	(5,119,723)
Total Vertex shareholders’ equity	2,906,116	2,028,579
Noncontrolling interest	28,365	13,727
Total shareholders’ equity	2,934,481	2,042,306
Total liabilities and shareholders’ equity	$ 4,620,840	$ 3,546,014