Condensed Consolidated Balance Sheets - USD ($) $ in Thousands	Jun. 30, 2018	Dec. 31, 2017
Current assets:
Cash and cash equivalents	$ 2,145,359	$ 1,665,412
Marketable securities	622,396	423,254
Restricted cash and cash equivalents (VIE)	8,510	1,489
Accounts receivable, net	393,439	281,343
Inventories	115,025	111,830
Prepaid expenses and other current assets	122,694	165,635
Total current assets	3,407,423	2,648,963
Property and equipment, net	815,928	789,437
Intangible assets	29,000	29,000
Goodwill	50,384	50,384
Other assets	32,651	28,230
Total assets	4,335,386	3,546,014
Current liabilities:
Accounts payable	83,034	73,994
Accrued expenses	479,120	443,961
Capital lease obligations, current portion	15,060	22,531
Early access sales accrual	290,457	232,401
Other liabilities, current portion	59,629	34,373
Total current liabilities	927,300	807,260
Capital lease obligations, excluding current portion	15,030	20,496
Deferred tax liability	9,335	6,341
Construction financing lease obligation, excluding current portion	562,645	563,406
Advance from collaborator, excluding current portion	80,602	78,431
Other liabilities, excluding current portion	25,591	27,774
Total liabilities	1,620,503	1,503,708
Commitments and contingencies
Shareholders’ equity:
Preferred stock, $0.01 par value; 1,000,000 shares authorized; none issued and outstanding	0	0
Common stock, $0.01 par value; 500,000,000 shares authorized, 254,882,837 and 253,253,362 shares issued and outstanding, respectively	2,542	2,512
Additional paid-in capital	7,357,042	7,157,362
Accumulated other comprehensive loss	(4,605)	(11,572)
Accumulated deficit	(4,668,751)	(5,119,723)
Total Vertex shareholders’ equity	2,686,228	2,028,579
Noncontrolling interest	28,655	13,727
Total shareholders’ equity	2,714,883	2,042,306
Total liabilities and shareholders’ equity	$ 4,335,386	$ 3,546,014