Condensed Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2018	Jun. 30, 2017	Jun. 30, 2018	Jun. 30, 2017
Revenues:
Revenues	$ 752,157	$ 544,135	$ 1,392,956	$ 1,258,853
Costs and expenses:
Cost of sales	104,382	71,205	175,995	118,193
Research and development expenses	337,532	289,451	648,085	563,014
Sales, general and administrative expenses	137,303	127,249	267,111	240,575
Restructuring expenses (income)	62	3,523	(14)	13,522
Total costs and expenses	579,279	491,428	1,091,177	935,304
Income from operations	172,878	52,707	301,779	323,549
Interest expense, net	(10,106)	(14,664)	(21,203)	(31,429)
Other income (expense), net	53,819	(2,537)	150,657	(3,081)
Income before provision for (benefit from) income taxes	216,591	35,506	431,233	289,039
Provision for (benefit from) income taxes	10,341	4,337	(2,318)	8,322
Net income	206,250	31,169	433,551	280,717
Loss (income) attributable to noncontrolling interest	1,110	(13,173)	(15,928)	(14,965)
Net income attributable to Vertex	$ 207,360	$ 17,996	$ 417,623	$ 265,752
Net income:
Basic (in dollars per share)	$ 0.82	$ 0.07	$ 1.65	$ 1.08
Diluted (in dollars per share)	$ 0.80	$ 0.07	$ 1.61	$ 1.06
Shares used in per share calculations:
Basic (in shares)	254,135	247,521	253,685	246,782
Diluted (in shares)	258,584	251,635	258,557	250,199
Product revenues, net
Revenues:
Revenues	$ 749,912	$ 513,988	$ 1,387,641	$ 994,610
Royalty revenues
Revenues:
Revenues	1,085	2,861	2,441	4,412
Collaborative revenues
Revenues:
Revenues	$ 1,160	$ 27,286	$ 2,874	$ 259,831