Collaborative Arrangements and Acquisitions - Parion Sciences, Inc. (Details) - Parion Sciences, Inc.	12 Months Ended
	Dec. 31, 2015 USD ($)
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Collaborative arrangement, up-front payment	$ 85,000,000
Prior to marketing approval, time period of notice required to terminate (in days)	90 days
Subsequent to marketing approval, time period of notice required to terminate (in days)	180 days
Change of control prior to clinical trial, time period of notice required to terminate (in days)	30 days
Term of agreement following first commercial sale (in years)	10 years
ENaC Inhibitors in CF
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Collaborative arrangement, development and regulatory potential milestone payments maximum	$ 485,000,000
Collaborative arrangement regulatory potential milestone payments maximum, global filling and approval	360,000,000
Enac Inhibitors in Non Cf
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Collaborative arrangement, development and regulatory potential milestone payments maximum	370,000,000
Additional Enac Inhibitors
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Collaborative arrangement, development and regulatory potential milestone payments maximum	$ 230,000,000