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Restructuring Liabilities	3 Months Ended
Restructuring Liabilities	Mar. 31, 2018
Restructuring and Related Activities [Abstract]
Restructuring Liabilities	Restructuring Liabilities The Company has adopted several plans to restructure its facilities and operations for which it has incurred restructuring expenses. During the three months ended March 31, 2018, the Company’s restructuring expenses were not significant. During the three months ended March 31, 2017, the Company’s restructuring expenses primarily related to its decision to consolidate its research activities into its Boston, Milton Park and San Diego locations commencing in February 2017. The Company closed its research site in Canada as a result of this decision affecting approximately 70 positions. The Company recorded a restructuring credit of $0.5 million and a restructuring charge of $9.2 million related to this restructuring event during the three months ended March 31, 2018 and 2017, respectively. As of March 31, 2018, the restructuring liability associated with this event relates to the lease for the research site in Canada that terminates in October 2018 and is not material to the Company’s condensed consolidated balance sheet. The Company does not anticipate any significant additional charges related to this restructuring event in the future.