Additional Balance Sheet Detail (Details) - USD ($) $ in Thousands	Dec. 31, 2017	Dec. 31, 2016
Prepaid and other current assets
Prepaid expenses	$ 62,475	$ 36,134
Collaborative accounts receivable	28,907	719
Other receivables and assets	74,253	34,400
Total	165,635	71,253
Accrued expenses
Payroll and benefits	113,026	86,387
Research, development and commercial contract costs	98,411	62,756
Product revenue allowances	119,919	86,533
Royalty payable	73,044	52,845
Other	39,561	26,728
Total	$ 443,961	$ 315,249