Intangible Assets and Goodwill (Details) - USD ($)	3 Months Ended								12 Months Ended
	Dec. 31, 2017	Sep. 30, 2017	Jun. 30, 2017	Mar. 31, 2017	Dec. 31, 2016	Sep. 30, 2016	Jun. 30, 2016	Mar. 31, 2016	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014
Indefinite-Lived Intangible Assets [Line Items]
Intangible assets	$ 29,000,000				$ 284,340,000				$ 29,000,000	$ 284,340,000
Intangible asset impairment charge	0	$ 255,340,000	$ 0	$ 0					255,340,000	0	$ 0
(Benefit from) provision for income taxes	10,257,000	(125,903,000)	$ 4,337,000	$ 3,985,000	(7,453,000)	$ 503,000	$ 18,130,000	$ 5,485,000	(107,324,000)	16,665,000	30,381,000
Goodwill	50,384,000				50,384,000				50,384,000	50,384,000
Parion Sciences, Inc
Indefinite-Lived Intangible Assets [Line Items]
Intangible asset impairment charge		255,300,000
(Benefit from) provision for income taxes		(126,200,000)
Variable Interest Entity, Primary Beneficiary
Indefinite-Lived Intangible Assets [Line Items]
Intangible assets	$ 29,000,000				$ 284,340,000				29,000,000	284,340,000
(Benefit from) provision for income taxes									(114,090,000)	$ 16,743,000	29,731,000
Variable Interest Entity, Primary Beneficiary | Parion Sciences, Inc
Indefinite-Lived Intangible Assets [Line Items]
Intangible assets											$ 255,300,000
Fair value of intangible asset		0
(Benefit from) provision for income taxes									14,800,000
Variable Interest Entity, Primary Beneficiary | BioAxone Biosciences, Inc
Indefinite-Lived Intangible Assets [Line Items]
Intangible assets												$ 29,000,000
Other Intangible Assets | Variable Interest Entity, Primary Beneficiary | Parion Sciences, Inc
Indefinite-Lived Intangible Assets [Line Items]
Intangible asset impairment charge		$ 255,300,000							255,300,000
(Benefit from) provision for income taxes									$ (97,700,000)