Collaborative Arrangements - BioAxone Biosciences, Inc. (Details) - BioAxone Biosciences, Inc - USD ($)		1 Months Ended	3 Months Ended
	Mar. 15, 2018	Oct. 31, 2014	Dec. 31, 2014
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Up-front payment			$ 10,000,000
Maximum license fees and milestone payments		$ 90,000,000.0
Variable interest entity, consolidated, carrying amount, in-process research and development intangible asset		29,000,000
Variable interest entity, consolidated, carrying amount, deferred tax liability		$ 11,300,000
Subsequent Event
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Collaborative arrangements, purchase option, term of extension of expiration date	1 year