Nature of Business and Accounting Policies - Revenue Recognition (Details) - USD ($) $ in Thousands	12 Months Ended
Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Accounting Policies [Abstract]
Accounts receivable, discount period	30 days
Activity related to product revenues allowances and reserve categories
Beginning Balance	$ 89,201	$ 49,296	$ 36,023
Provision related to current period sales	222,521	163,922	81,205
Adjustments related to prior period sales	(9,638)	(104)	(20,852)
Credits/payments made	(179,401)	(123,913)	(47,080)
Ending Balance	$ 122,683	89,201	49,296
Prior period adjustment as total percent of net product revenues (less than)	0.50%
Customer deposits	$ 232,401	73,416
New accounting pronouncement or change in accounting principle, cumulative effect of change on equity or net assets	6,500
Trade Allowances
Activity related to product revenues allowances and reserve categories
Beginning Balance	2,568	2,089	1,463
Provision related to current period sales	25,892	20,075	10,890
Adjustments related to prior period sales	(189)	(90)	(214)
Credits/payments made	(25,507)	(19,506)	(10,050)
Ending Balance	2,764	2,568	2,089
Rebates, Chargebacks and Discounts
Activity related to product revenues allowances and reserve categories
Beginning Balance	81,927	44,669	29,102
Provision related to current period sales	176,996	134,198	65,781
Adjustments related to prior period sales	(8,943)	154	(19,410)
Credits/payments made	(137,765)	(97,094)	(30,804)
Ending Balance	112,215	81,927	44,669
Product Returns
Activity related to product revenues allowances and reserve categories
Beginning Balance	3,492	1,228	4,713
Provision related to current period sales	4,038	3,047	779
Adjustments related to prior period sales	(13)	(17)	(993)
Credits/payments made	(4,496)	(766)	(3,271)
Ending Balance	3,021	3,492	1,228
Other Incentives
Activity related to product revenues allowances and reserve categories
Beginning Balance	1,214	1,310	745
Provision related to current period sales	15,595	6,602	3,755
Adjustments related to prior period sales	(493)	(151)	(235)
Credits/payments made	(11,633)	(6,547)	(2,955)
Ending Balance	$ 4,683	$ 1,214	$ 1,310

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The current portion of money or property received from customers which is either to be returned upon satisfactory contract completion or applied to customer receivables in accordance with the terms of the contract or the understandings.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 210
-SubTopic 10
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Amount of cumulative effect of the change in accounting principle or new accounting pronouncement on retained earnings or other components of equity or net assets in the statement of financial position as of the beginning of the earliest period presented.

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Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
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Amount of increase (decrease) in the allowances and reserves, which consist of the valuation and qualifying accounts that are either netted against the cost of an asset or that reflect a liability established to represent expected future costs, from adjustments.

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Total of allowances and reserves, the valuation and qualifying accounts that are either netted against the cost of an asset (in order to value it at its carrying value) or that reflect a liability established to represent expected future costs.

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Prior Period Adjustment as Total Percent of Net Product Revenues

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