Segment Information (Tables)

12 Months Ended

Dec. 31, 2017

Segment Reporting [Abstract]

Revenues by Product

Product revenues, net consisted of the following:

	2017		2016		2015
	(in thousands)
ORKAMBI	$	1,320,850	$	979,590	$	350,663
KALYDECO	844,630		703,432		631,674
INCIVEK	—		610		17,987
Total product revenues, net	$	2,165,480	$	1,683,632	$	1,000,324

Revenues and Property and Equipment by Location

Property and equipment, net by location consisted of the following:

	As of December 31,
	2017		2016
	(in thousands)
United States	$	753,128	$	665,552
Outside of the United States
United Kingdom	31,279		26,921
Other	5,030		5,889
Total property and equipment, net outside of the United States	36,309		32,810
Total property and equipment, net	$	789,437	$	698,362

Total revenues from external customers and collaborators by geographic region consisted of the following:

	2017		2016		2015
	(in thousands)
United States	$	1,986,786	$	1,321,807	$	763,316
Outside of the United States
Europe	420,317		320,456		219,596
Other	81,549		59,914		49,424
Total revenues outside of the United States	501,866		380,370		269,020
Total revenues	$	2,488,652	$	1,702,177	$	1,032,336

Significant Customers

Gross revenues and accounts receivable from each of the Company’s customers who individually accounted for 10% or more of total gross revenues and/or 10% or more of total gross accounts receivable consisted of the following:

	Percent of Total Gross Revenues						Percent of Gross Accounts Receivable
	Year Ended December 31,						As of December 31,
	2017		2016		2015		2017		2016
Walgreen Co.	17	%	19	%	20	%	20	%	15	%
Accredo/Curascript	14	%	15	%	15	%	12	%	10	%
CVS/Caremark	<10	%	19	%	17	%	n/a		17	%