Collaborative Arrangements (Tables)

12 Months Ended

Dec. 31, 2017

Organization, Consolidation and Presentation of Financial Statements [Abstract]

Schedule of collaborative arrangement activity net loss attributable to noncontrolling interest

An aggregate summary of net loss attributable to noncontrolling interest related to the Company’s VIEs for the three years ended December 31, 2017 was as follows:

	2017			2016			2015
	(in thousands)
Loss attributable to noncontrolling interest before (benefit from) provision for income taxes and changes in fair value of contingent payments	$	223,379		$	10,086		$	6,646
(Benefit from) provision for income taxes	(114,090		)	16,743			29,731
Decrease (increase) in fair value of contingent payments	62,560			(54,850		)	(4,530		)
Net loss (income) attributable to noncontrolling interest	$	171,849		$	(28,021	)	$	31,847

Schedule of changes in fair value of contingent payments

During three years ended December 31, 2017, the (increases) decreases in the fair value of the contingent payments related to the Company’s VIEs were as follows:

	2017			2016			2015
	(in thousands)
Parion	$	63,460		$	(64,800	)	$	(3,660	)
BioAxone	(900		)	9,950			(870		)

Scheulde of fair value of consideration payments

The fair value of the contingent payments related to the Parion Agreement and the BioAxone Agreement as of the dates set forth in the table were as follows:

	December 31, 2017		December 31, 2016
	(in thousands)
Parion	$	—	$	238,800
BioAxone	18,900		18,000

Schedule of collaborative arrangement summary of items related to variable interest entities

Amounts as of December 31, 2017 related to BioAxone while amounts as of December 31, 2016 related to Parion and BioAxone.

	December 31, 2017		December 31, 2016
	(in thousands)
Restricted cash and cash equivalents (VIE)	$	1,489	$	47,762
Prepaid expenses and other current assets	22		6,812
Intangible assets	29,000		284,340
Other assets	256		399
Accounts payable	1,021		415
Taxes payable	2,171		1,330
Other current liabilities	—		2,137
Deferred tax liability, net	4,756		131,446
Other liabilities	—		300
Noncontrolling interest	13,727		181,609