Segment Information

12 Months Ended

Dec. 31, 2017

Segment reporting is prepared on the same basis that the Company’s chief executive officer, who is the Company’s chief operating decision maker, manages the business, makes operating decisions and assesses performance. The Company operates in one segment, pharmaceuticals. Enterprise-wide disclosures about revenues, significant customers, and property and equipment, net by location are presented below.

Revenues by Product

Product revenues, net consisted of the following:



	2017		2016		2015
	(in thousands)
ORKAMBI	$	1,320,850	$	979,590	$	350,663
KALYDECO	844,630		703,432		631,674
INCIVEK	—		610		17,987
Total product revenues, net	$	2,165,480	$	1,683,632	$	1,000,324

Revenues by Geographic Location

Net product revenues are attributed to countries based on the location of the customer. Collaborative and royalty revenues are attributed to countries based on the location of the Company’s subsidiary associated with the collaborative arrangement related to such revenues. Total revenues from external customers and collaborators by geographic region consisted of the following:



	2017		2016		2015
	(in thousands)
United States	$	1,986,786	$	1,321,807	$	763,316
Outside of the United States
Europe	420,317		320,456		219,596
Other	81,549		59,914		49,424
Total revenues outside of the United States	501,866		380,370		269,020
Total revenues	$	2,488,652	$	1,702,177	$	1,032,336

In 2017, 2016 and 2015, revenues attributable to the U.K. were the largest contributor to the Company’s European revenues.

Significant Customers

Gross revenues and accounts receivable from each of the Company’s customers who individually accounted for 10% or more of total gross revenues and/or 10% or more of total gross accounts receivable consisted of the following:



	Percent of Total Gross Revenues						Percent of Gross Accounts Receivable
	Year Ended December 31,						As of December 31,
	2017		2016		2015		2017		2016
Walgreen Co.	17	%	19	%	20	%	20	%	15	%
Accredo/Curascript	14	%	15	%	15	%	12	%	10	%
CVS/Caremark	<10	%	19	%	17	%	n/a		17	%

Property and Equipment, Net by Location

Property and equipment, net by location consisted of the following:



	As of December 31,
	2017		2016
	(in thousands)
United States	$	753,128	$	665,552
Outside of the United States
United Kingdom	31,279		26,921
Other	5,030		5,889
Total property and equipment, net outside of the United States	36,309		32,810
Total property and equipment, net	$	789,437	$	698,362