Condensed Consolidated Statements of Cash Flows (unaudited) - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2017	Sep. 30, 2016
Cash flows from operating activities:
Net loss	$ (10,550)	$ (111,790)
Adjustments to reconcile net loss to net cash provided by operating activities:
Stock-based compensation expense	215,334	178,623
Depreciation and amortization expense	44,965	45,947
Write-downs of inventories to net realizable value	11,138	0
Deferred income taxes	(113,969)	23,544
Impairment of property and equipment	1,946	0
Intangible asset impairment charge	255,340	0
Acquired in-process research & development	160,000	0
Deconsolidation of VIE	76,644	0
Other non-cash items, net	(4,787)	(904)
Changes in operating assets and liabilities:
Accounts receivable, net	(54,455)	(9,760)
Inventories	(28,570)	(11,536)
Prepaid expenses and other assets	(90,006)	(8,979)
Accounts payable	6,925	(21,532)
Accrued expenses and other liabilities	148,102	26,121
Accrued restructuring expense	(3,863)	(8,151)
Deferred revenues	3,237	(10,204)
Net cash provided by operating activities	617,431	91,379
Cash flows from investing activities:
Purchases of marketable securities	(431,653)	(616,625)
Maturities of marketable securities	247,149	535,379
Expenditures for property and equipment	(56,817)	(41,775)
Purchase of in-process research & development	(160,000)	0
(Decrease) increase in restricted cash and cash equivalents (VIE)	(15,643)	20,490
Investment in equity securities	0	(23,075)
Decrease (increase) in other assets	380	(93)
Net cash used in investing activities	(416,584)	(125,699)
Cash flows from financing activities:
Issuances of common stock under benefit plans	298,205	51,165
Payments on revolving credit facility	(300,000)	0
Advance from collaborator	10,000	0
Payments on capital lease obligations	(14,188)	(13,330)
Proceeds from capital lease financing	0	2,030
Payments on construction financing lease obligation	(412)	(356)
Proceeds related to construction financing lease obligation	4,700	0
Repayments of advanced funding	(3,132)	0
Net cash (used in) provided by financing activities	(4,827)	39,509
Effect of changes in exchange rates on cash	5,001	(265)
Net increase in cash and cash equivalents	201,021	4,924
Cash and cash equivalents—beginning of period	1,183,945	714,768
Cash and cash equivalents—end of period	1,384,966	719,692
Supplemental disclosure of cash flow information:
Cash paid for interest	51,990	64,662
Cash paid for income taxes	4,154	1,617
Capitalization of costs related to construction financing lease obligation	33,827	824
Issuances of common stock from employee benefit plans receivable	$ 868	$ 19