Intangible Assets and Goodwill (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2017	Sep. 30, 2016	Sep. 30, 2017	Sep. 30, 2016	Dec. 31, 2016	Dec. 31, 2015	Jun. 04, 2015	Dec. 31, 2014
Indefinite-Lived Intangible Assets [Line Items]
Intangible assets	$ 29,000		$ 29,000		$ 284,340
Intangible asset impairment charge	255,340	$ 0	255,340	$ 0
Income tax benefit	125,903	(503)	117,581	(24,118)
Goodwill	50,384		50,384		50,384
Parion Sciences, Inc.
Indefinite-Lived Intangible Assets [Line Items]
Intangible assets							$ 255,300
Intangible asset impairment charge	255,300
Income tax benefit	126,200
Variable Interest Entity, Primary Beneficiary
Indefinite-Lived Intangible Assets [Line Items]
Intangible assets	29,000		29,000		$ 284,340
Income tax benefit	120,181	$ 510	111,658	$ (20,063)
Variable Interest Entity, Primary Beneficiary | Parion Sciences, Inc.
Indefinite-Lived Intangible Assets [Line Items]
Intangible assets						$ 255,300
Income tax benefit	(7,400)		(14,800)
Variable Interest Entity, Primary Beneficiary | BioAxone Biosciences Inc.
Indefinite-Lived Intangible Assets [Line Items]
Intangible assets								$ 29,000
In-process research development intangible asset | Variable Interest Entity, Primary Beneficiary | Parion Sciences, Inc.
Indefinite-Lived Intangible Assets [Line Items]
Intangible asset impairment charge	255,300		255,300
Income tax benefit	$ 97,700		$ 97,700