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Inventories - Schedule of Inventories (Details) - USD ($)
$ in Thousands
Sep. 30, 2017
Dec. 31, 2016
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]    
Raw materials $ 12,678 $ 6,348
Work-in-process 67,826 56,672
Finished goods 17,688 14,584
Total Inventories 98,192 $ 77,604
Tezacaftor    
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]    
Capitalized inventory $ 9,600