Collaborative Arrangements and Acquisitions - Aggregate VIE Financial Information, Summary of Net Income Attributable to Noncontrolling Interest (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2017	Sep. 30, 2016	Sep. 30, 2017	Sep. 30, 2016
Variable Interest Entity, Primary Beneficiary, Does Not Hold Majority Voting Interest, Disclosures [Abstract]
(Benefit from) provision for income taxes	$ (125,903)	$ 503	$ (117,581)	$ 24,118
Net loss (income) attributable to noncontrolling interest	(188,315)	(696)	(173,350)	33,207
Variable Interest Entity, Primary Beneficiary
Variable Interest Entity, Primary Beneficiary, Does Not Hold Majority Voting Interest, Disclosures [Abstract]
Loss attributable to noncontrolling interest before (benefit from) provision for income taxes and changes in fair value of contingent payments	238,946	2,406	222,448	6,080
(Benefit from) provision for income taxes	(120,181)	(510)	(111,658)	20,063
Decrease (increase) in fair value of contingent payments	69,550	(1,200)	62,560	(59,350)
Net loss (income) attributable to noncontrolling interest	(188,315)	(696)	(173,350)	33,207
Parion Sciences, Inc.
Variable Interest Entity, Primary Beneficiary, Does Not Hold Majority Voting Interest, Disclosures [Abstract]
(Benefit from) provision for income taxes	(126,200)
Decrease (increase) in fair value of contingent payments	69,600
Parion Sciences, Inc. | Variable Interest Entity, Primary Beneficiary
Variable Interest Entity, Primary Beneficiary, Does Not Hold Majority Voting Interest, Disclosures [Abstract]
(Benefit from) provision for income taxes	7,400		14,800
Decrease (increase) in fair value of contingent payments	$ 69,550	$ (1,100)	$ 63,460	$ (58,500)