Restructuring Liabilities - Narrative (Details) ft² in Thousands	1 Months Ended	3 Months Ended	12 Months Ended
	Feb. 28, 2017 position facility	Sep. 30, 2014 facility	Dec. 31, 2015 USD ($) ft² lease	Dec. 31, 2003	Jun. 30, 2017 USD ($)	Mar. 31, 2017 USD ($)	Dec. 31, 2016 USD ($)	Jun. 30, 2016 USD ($)	Mar. 31, 2016 USD ($)
Research and Development Restructuring
Restructuring Cost and Reserve [Line Items]
Restructuring and related cost, number of facilities expected to close | facility	1
Restructuring and related cost, number of positions eliminated | position	70
Restructuring and related cost, expected cost					$ 12,400,000
Restructuring reserve					3,507,000	$ 3,727,000	$ 0
Kendall Restructuring
Restructuring Cost and Reserve [Line Items]
Lease term (in years)				15 years
Restructuring and related activities, leased office space, maximum percentage used - not more than				50.00%
Restructuring reserve			$ 7,944,000		1,990,000	2,525,000	4,328,000	$ 6,388,000	$ 7,224,000
Fan Pier Move Restructuring
Restructuring Cost and Reserve [Line Items]
Number of facilities decommissioned | facility		3
Number of leases terminated | lease			2
Area of real estate property (in square feet) | ft²			120
Discount rate related to leases (percent)			9.00%
Restructuring reserve			$ 5,964,000		1,521,000	$ 1,995,000	$ 3,626,000	4,863,000	5,449,000
Other Restructuring
Restructuring Cost and Reserve [Line Items]
Restructuring reserve			$ 1,450,000		0			$ 1,233,000	$ 1,262,000
Employee Severance | Research and Development Restructuring
Restructuring Cost and Reserve [Line Items]
Restructuring and related cost, expected cost					6,900,000
Asset Impairments | Research and Development Restructuring
Restructuring Cost and Reserve [Line Items]
Restructuring and related cost, expected cost					2,200,000
Facility Closing | Research and Development Restructuring
Restructuring Cost and Reserve [Line Items]
Restructuring and related cost, expected cost					$ 3,300,000