Stock-based Compensation Expense - (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2017	Jun. 30, 2016	Jun. 30, 2017	Jun. 30, 2016
Stock-based compensation expense:
Less stock-based compensation expense capitalized to inventories	$ (1,485)	$ (928)	$ (2,293)	$ (1,773)
Total stock-based compensation included in costs and expenses	72,582	61,942	141,564	117,414
Research and development expenses
Stock-based compensation expense:
Total stock-based compensation included in costs and expenses	43,832	40,640	88,669	75,088
Sales, general and administrative expenses
Stock-based compensation expense:
Total stock-based compensation included in costs and expenses	28,750	21,302	52,895	42,326
Stock options
Stock-based compensation expense:
Stock-based compensation expense by type of award:	27,915	31,826	54,896	58,086
Type of award:
Unrecognized Expense	165,047		$ 165,047
Weighted-average Recognition Period			2 years 6 months 4 days
Restricted stock and restricted stock units
Stock-based compensation expense:
Stock-based compensation expense by type of award:	43,906	29,608	$ 84,651	57,141
Type of award:
Unrecognized Expense	249,474		$ 249,474
Weighted-average Recognition Period			2 years 4 months 28 days
ESPP share issuances
Stock-based compensation expense:
Stock-based compensation expense by type of award:	2,246	$ 1,436	$ 4,310	$ 3,960
Type of award:
Unrecognized Expense	$ 5,064		$ 5,064
Weighted-average Recognition Period			7 months 13 days