Collaborative Arrangements and Acquisitions - Aggregate VIE Financial Information, Contingent Consideration Liability (Details) - Variable Interest Entity, Primary Beneficiary - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2017	Jun. 30, 2016	Jun. 30, 2017	Jun. 30, 2016	Dec. 31, 2016
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Increase in the fair value of the contingent payments	$ 3,260	$ 48,720	$ 6,990	$ 58,150
Parion Sciences, Inc.
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Increase in the fair value of the contingent payments	3,260	48,400	6,090	57,400
Contingent consideration, liability	244,890		244,890		$ 238,800
BioAxone Biosciences Inc.
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Increase in the fair value of the contingent payments	0	$ 320	900	$ 750
Contingent consideration, liability	$ 18,900		$ 18,900		$ 18,000