Stock-based Compensation Expense - (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2017	Mar. 31, 2016
Stock-based compensation expense:
Less stock-based compensation expense capitalized to inventories	$ (808)	$ (845)
Total stock-based compensation included in costs and expenses	68,982	55,472
Stock options
Stock-based compensation expense:
Stock-based compensation expense by type of award:	26,981	26,260
Type of award:
Unrecognized Expense	$ 200,906
Weighted-average recognition period (in years)	2 years 7 months 24 days
Restricted stock and restricted stock units
Stock-based compensation expense:
Stock-based compensation expense by type of award:	$ 40,745	27,533
Type of award:
Unrecognized Expense	$ 291,088
Weighted-average recognition period (in years)	2 years 6 months 26 days
ESPP share issuances
Stock-based compensation expense:
Stock-based compensation expense by type of award:	$ 2,064	2,524
Type of award:
Unrecognized Expense	$ 2,016
Weighted-average recognition period (in years)	5 months 5 days
Research and development expenses
Stock-based compensation expense:
Total stock-based compensation included in costs and expenses	$ 44,837	34,448
Sales, general and administrative expenses
Stock-based compensation expense:
Total stock-based compensation included in costs and expenses	$ 24,145	$ 21,024