Fair Value Measurements (Details) - USD ($) $ in Thousands	Mar. 31, 2017	Dec. 31, 2016
Recurring basis
Financial instruments carried at fair value (asset position):
Total financial assets	$ 745,160	$ 546,765
Financial instruments carried at fair value (liability position):
Total financial liabilities	(699)	(144)
Recurring basis \| Money market funds
Financial instruments carried at fair value (asset position):
Cash equivalents	313,629	280,560
Recurring basis \| Government-sponsored enterprise securities
Financial instruments carried at fair value (asset position):
Marketable securities		15,508
Recurring basis \| Corporate equity securities
Financial instruments carried at fair value (asset position):
Marketable securities	69,372	64,560
Recurring basis \| Corporate debt securities
Financial instruments carried at fair value (asset position):
Cash equivalents	11,027
Marketable securities	203,181	111,140
Recurring basis \| Commercial paper
Financial instruments carried at fair value (asset position):
Cash equivalents	6,834
Marketable securities	132,550	59,404
Recurring basis \| Level 1
Financial instruments carried at fair value (asset position):
Total financial assets	400,862	360,628
Financial instruments carried at fair value (liability position):
Total financial liabilities	0	0
Recurring basis \| Level 1 \| Money market funds
Financial instruments carried at fair value (asset position):
Cash equivalents	313,629	280,560
Recurring basis \| Level 1 \| Government-sponsored enterprise securities
Financial instruments carried at fair value (asset position):
Marketable securities		15,508
Recurring basis \| Level 1 \| Corporate equity securities
Financial instruments carried at fair value (asset position):
Marketable securities	69,372	64,560
Recurring basis \| Level 1 \| Corporate debt securities
Financial instruments carried at fair value (asset position):
Cash equivalents	11,027
Marketable securities	0	0
Recurring basis \| Level 1 \| Commercial paper
Financial instruments carried at fair value (asset position):
Cash equivalents	6,834
Marketable securities	0	0
Recurring basis \| Level 2
Financial instruments carried at fair value (asset position):
Total financial assets	344,298	186,137
Financial instruments carried at fair value (liability position):
Total financial liabilities	(699)	(144)
Recurring basis \| Level 2 \| Money market funds
Financial instruments carried at fair value (asset position):
Cash equivalents	0	0
Recurring basis \| Level 2 \| Government-sponsored enterprise securities
Financial instruments carried at fair value (asset position):
Marketable securities		0
Recurring basis \| Level 2 \| Corporate equity securities
Financial instruments carried at fair value (asset position):
Marketable securities	0	0
Recurring basis \| Level 2 \| Corporate debt securities
Financial instruments carried at fair value (asset position):
Cash equivalents	0
Marketable securities	203,181	111,140
Recurring basis \| Level 2 \| Commercial paper
Financial instruments carried at fair value (asset position):
Cash equivalents	0
Marketable securities	132,550	59,404
Recurring basis \| Level 3
Financial instruments carried at fair value (asset position):
Total financial assets	0	0
Financial instruments carried at fair value (liability position):
Total financial liabilities	0	0
Recurring basis \| Level 3 \| Money market funds
Financial instruments carried at fair value (asset position):
Cash equivalents	0	0
Recurring basis \| Level 3 \| Government-sponsored enterprise securities
Financial instruments carried at fair value (asset position):
Marketable securities		0
Recurring basis \| Level 3 \| Corporate equity securities
Financial instruments carried at fair value (asset position):
Marketable securities	0	0
Recurring basis \| Level 3 \| Corporate debt securities
Financial instruments carried at fair value (asset position):
Cash equivalents	0
Marketable securities	0	0
Recurring basis \| Level 3 \| Commercial paper
Financial instruments carried at fair value (asset position):
Cash equivalents	0
Marketable securities	0	0
Prepaid and other current assets \| Foreign currency forward contracts \| Recurring basis
Financial instruments carried at fair value (asset position):
Foreign currency forward contracts	8,318	14,407
Prepaid and other current assets \| Foreign currency forward contracts \| Recurring basis \| Level 1
Financial instruments carried at fair value (asset position):
Foreign currency forward contracts	0	0
Prepaid and other current assets \| Foreign currency forward contracts \| Recurring basis \| Level 2
Financial instruments carried at fair value (asset position):
Foreign currency forward contracts	8,318	14,407
Prepaid and other current assets \| Foreign currency forward contracts \| Recurring basis \| Level 3
Financial instruments carried at fair value (asset position):
Foreign currency forward contracts	0	0
Other Assets \| Foreign currency forward contracts \| Recurring basis
Financial instruments carried at fair value (asset position):
Foreign currency forward contracts	249	1,186
Other Assets \| Foreign currency forward contracts \| Recurring basis \| Level 1
Financial instruments carried at fair value (asset position):
Foreign currency forward contracts	0	0
Other Assets \| Foreign currency forward contracts \| Recurring basis \| Level 2
Financial instruments carried at fair value (asset position):
Foreign currency forward contracts	249	1,186
Other Assets \| Foreign currency forward contracts \| Recurring basis \| Level 3
Financial instruments carried at fair value (asset position):
Foreign currency forward contracts	0	0
Other liabilities, current portion \| Foreign currency forward contracts \| Recurring basis
Financial instruments carried at fair value (liability position):
Derivative liability current	(613)	(144)
Other liabilities, current portion \| Foreign currency forward contracts \| Recurring basis \| Level 1
Financial instruments carried at fair value (liability position):
Derivative liability current	0	0
Other liabilities, current portion \| Foreign currency forward contracts \| Recurring basis \| Level 2
Financial instruments carried at fair value (liability position):
Derivative liability current	(613)	(144)
Other liabilities, current portion \| Foreign currency forward contracts \| Recurring basis \| Level 3
Financial instruments carried at fair value (liability position):
Derivative liability current	0	$ 0
Other liabilities, excluding current portion \| Foreign currency forward contracts \| Recurring basis
Financial instruments carried at fair value (liability position):
Derivative liability, noncurrent	(86)
Other liabilities, excluding current portion \| Foreign currency forward contracts \| Recurring basis \| Level 1
Financial instruments carried at fair value (liability position):
Derivative liability, noncurrent	0
Other liabilities, excluding current portion \| Foreign currency forward contracts \| Recurring basis \| Level 2
Financial instruments carried at fair value (liability position):
Derivative liability, noncurrent	(86)
Other liabilities, excluding current portion \| Foreign currency forward contracts \| Recurring basis \| Level 3
Financial instruments carried at fair value (liability position):
Derivative liability, noncurrent	0
Variable Interest Entity, Primary Beneficiary \| BioAxone Biosciences Inc \| Level 1
Financial instruments carried at fair value (liability position):
Cash and cash equivalents	$ 44,100

Fair value portion of probable future economic benefits obtained or controlled by an entity as a result of past transactions or events.

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