Condensed Consolidated Statements of Operations (unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2017	Mar. 31, 2016
Revenues:
Product revenues, net	$ 480,622	$ 394,410
Royalty revenues	1,551	3,596
Collaborative revenues	232,545	74
Total revenues	714,718	398,080
Costs and expenses:
Cost of product revenues	46,242	49,789
Royalty expenses	746	860
Research and development expenses	273,563	255,860
Sales, general and administrative expenses	113,326	105,214
Restructuring expenses, net	9,999	687
Total costs and expenses	443,876	412,410
Income (loss) from operations	270,842	(14,330)
Interest expense, net	(16,765)	(20,698)
Other (expenses) income, net	(544)	4,411
Income (loss) before provision for income taxes	253,533	(30,617)
Provision for income taxes	3,985	5,485
Net income (loss)	249,548	(36,102)
Income attributable to noncontrolling interest	(1,792)	(5,529)
Net income (loss) attributable to Vertex	$ 247,756	$ (41,631)
Net income (loss):
Basic (in dollars per share)	$ 1.01	$ (0.17)
Diluted (in dollars per share)	$ 0.99	$ (0.17)
Shares used in per share calculations:
Basic (in shares)	246,024	243,831
Diluted (in shares)	248,700	243,831