Additional Balance Sheet Detail (Details) - USD ($) $ in Thousands	Dec. 31, 2016	Dec. 31, 2015
Prepaid and other current assets
Prepaid expenses	$ 36,134	$ 22,058
Fair value foreign currency forward contracts	14,407	5,161
Taxes receivable	3,213	14,682
Other	16,780	12,835
Total	70,534	54,736
Accrued expenses
Payroll and benefits	86,387	87,873
Research, development and commercial contract costs	62,756	55,677
Product revenue allowances	86,533	47,209
Royalty payable	52,845	60,191
Taxes payable and reserves (including VIE taxes payable)	6,883	30,953
Professional fees	6,512	7,455
Interest	1,390	4,642
Other	11,943	11,820
Total	315,249	305,820
Other liabilities, current portion
Advance from CFFT	73,423	0
Deferred rent	19,551	22,235
Other Sundry Liabilities, Noncurrent	9,148	9,543
Total non-current liabilities	$ 102,122	$ 31,778