Intangible Assets and Goodwill (Details) - USD ($) $ in Thousands	1 Months Ended
	Jun. 30, 2015	Dec. 31, 2016	Dec. 31, 2015	Jun. 04, 2015	Oct. 31, 2014
Indefinite-Lived Intangible Assets [Line Items]
Intangible assets		$ 284,340	$ 284,340
Goodwill		50,384	50,384
BioAxone Biosciences, Inc
Indefinite-Lived Intangible Assets [Line Items]
In-process research and development intangible assets					$ 29,000
Parion Sciences, Inc
Indefinite-Lived Intangible Assets [Line Items]
Intangible assets	$ 255,340
Goodwill				$ 10,468
Variable Interest Entity, Primary Beneficiary
Indefinite-Lived Intangible Assets [Line Items]
Intangible assets		284,340	284,340
Goodwill		19,391	19,391
Variable Interest Entity, Primary Beneficiary | Parion Sciences, Inc
Indefinite-Lived Intangible Assets [Line Items]
In-process research and development intangible assets		$ 284,300	$ 284,300
Intangible assets	$ 255,300
Indefinite-lived Intangible Assets | Variable Interest Entity, Primary Beneficiary | Parion Sciences, Inc
Indefinite-Lived Intangible Assets [Line Items]
Discount rate used to estimate fair value (percent)	7.10%