Collaborative Arrangements - Aggregate VIE Financial Information (Details) - USD ($) $ in Thousands	3 Months Ended								12 Months Ended
	Dec. 31, 2016	Sep. 30, 2016	Jun. 30, 2016	Mar. 31, 2016	Dec. 31, 2015	Sep. 30, 2015	Jun. 30, 2015	Mar. 31, 2015	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014	Jun. 04, 2015
Variable Interest Entity, Primary Beneficiary, Does Not Hold Majority Voting Interest, Disclosures [Abstract]
Loss attributable to noncontrolling interest before provision for income taxes									$ (28,021)	$ 31,847	$ 4,190
Provision for income taxes	$ (7,453)	$ 503	$ 18,130	$ 5,485	$ (1,379)	$ 1,330	$ 30,131	$ 299	16,665	30,381	6,958
Net (income) loss attributable to noncontrolling interest	5,186	$ 696	$ (28,374)	$ (5,529)
Variable Interest Entity, Consolidated, Carrying Amount, Assets and Liabilities, Net:
Restricted cash and cash equivalents (VIE)	47,762				78,910				47,762	78,910
Prepaid expenses and other current assets	70,534				54,736				70,534	54,736
Intangible assets	284,340				284,340				284,340	284,340
Goodwill	50,384				50,384				50,384	50,384
Other assets	11,833				6,912				11,833	6,912
Accounts payable	61,451				74,942				61,451	74,942
Other current liabilities	315,249				305,820				315,249	305,820
Deferred tax liability	134,063				110,439				134,063	110,439
Other liabilities	102,122				31,778				102,122	31,778
Noncontrolling interest	181,609				153,661				181,609	153,661
BioAxone Biosciences, Inc
Variable Interest Entity, Primary Beneficiary, Does Not Hold Majority Voting Interest, Disclosures [Abstract]
Decrease (increase) in fair value of contingent payments									10,000	(900)	(500)
Contingent consideration liability	18,000				28,000				18,000	28,000
Variable Interest Entity, Consolidated, Carrying Amount, Assets and Liabilities, Net:
Deferred tax liability	134,000				110,400				134,000	110,400
Parion Sciences, Inc
Variable Interest Entity, Primary Beneficiary, Does Not Hold Majority Voting Interest, Disclosures [Abstract]
Decrease (increase) in fair value of contingent payments									(64,800)	(3,600)
Contingent consideration liability	238,800				179,000				238,800	179,000
Variable Interest Entity, Consolidated, Carrying Amount, Assets and Liabilities, Net:
Intangible assets							255,340
Goodwill												$ 10,468
Variable Interest Entity, Primary Beneficiary
Variable Interest Entity, Primary Beneficiary, Does Not Hold Majority Voting Interest, Disclosures [Abstract]
Loss attributable to noncontrolling interest before provision for income taxes									10,086	6,646	764
Provision for income taxes									16,743	29,731	3,876
Decrease (increase) in fair value of contingent payments									(54,850)	(4,530)	(450)
Net (income) loss attributable to noncontrolling interest									(28,021)	31,847	$ 4,190
Variable Interest Entity, Consolidated, Carrying Amount, Assets and Liabilities, Net:
Restricted cash and cash equivalents (VIE)	47,762				78,910				47,762	78,910
Prepaid expenses and other current assets	6,812				3,138				6,812	3,138
Intangible assets	284,340				284,340				284,340	284,340
Goodwill	19,391				19,391				19,391	19,391
Other assets	399				455				399	455
Accounts payable	415				676				415	676
Taxes payable	1,330				24,554				1,330	24,554
Other current liabilities	2,137				7,100				2,137	7,100
Deferred tax liability	131,446				110,438				131,446	110,438
Other liabilities	300				300				300	300
Noncontrolling interest	$ 181,609				$ 153,661				$ 181,609	$ 153,661
Variable Interest Entity, Primary Beneficiary | Parion Sciences, Inc
Variable Interest Entity, Consolidated, Carrying Amount, Assets and Liabilities, Net:
Intangible assets							$ 255,300