Condensed Consolidated Statements of Cash Flows (unaudited) - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2016	Sep. 30, 2015
Cash flows from operating activities:
Net loss	$ (111,790)	$ (513,512)
Adjustments to reconcile net loss to net cash provided by (used in) operating activities:
Stock-based compensation expense	178,623	186,379
Depreciation and amortization expense	45,947	46,596
Deferred income taxes	23,544	7,793
Other non-cash items, net	(904)	(2,876)
Changes in operating assets and liabilities:
Accounts receivable, net	(9,760)	(88,735)
Inventories	(11,536)	(16,127)
Prepaid expenses and other assets	(8,979)	(23,737)
Accounts payable	(21,532)	6,283
Accrued expenses and other liabilities	26,121	45,163
Accrued restructuring expense	(8,151)	(28,051)
Deferred revenues	(10,204)	(13,751)
Net cash provided by (used in) operating activities	91,379	(394,575)
Cash flows from investing activities:
Purchases of marketable securities	(616,625)	(292,135)
Maturities of marketable securities	535,379	804,588
Expenditures for property and equipment	(41,775)	(32,775)
Decrease in restricted cash and cash equivalents (VIE)	20,490	14,830
Investments in other entities	(20,000)	0
Investment in CRISPR Series B preferred stock	(3,075)	0
(Increase) decrease in other assets	(90)	(982)
Increase in restricted cash and cash equivalents	(3)	(21,980)
Payment for acquisition of variable interest entity	0	(80,000)
Net cash (used in) provided by investing activities	(125,699)	391,546
Cash flows from financing activities:
Issuances of common stock under benefit plans	51,165	139,689
Payments on capital lease obligations	(13,330)	(16,515)
Payments on construction financing lease obligation	(356)	(281)
Proceeds from capital lease financing	2,030	13,386
Net cash provided by financing activities	39,509	136,279
Effect of changes in exchange rates on cash	(265)	(2,259)
Net increase in cash and cash equivalents	4,924	130,991
Cash and cash equivalents—beginning of period	714,768	625,259
Cash and cash equivalents—end of period	719,692	756,250
Supplemental disclosure of cash flow information:
Cash paid for interest	64,662	64,231
Cash received from (paid for) income taxes	1,617	(1,261)
Capitalization of costs related to construction financing lease obligation	824	0
Issuances of common stock exercises from employee benefit plans receivable	$ 19	$ (236)