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Collaborative Arrangements - Parion Sciences, Inc. (Details) - USD ($)
Jun. 04, 2015
Jun. 30, 2016
Dec. 31, 2015
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]      
Intangible assets   $ 284,340,000 $ 284,340,000
Parion Sciences, Inc      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]      
Up-front payment $ 80,000,000    
Prior to marketing approval, time period of notice required to terminate (in days) 90 days    
Subsequent to marketing approval, time period of notice required to terminate (in days) 180 days    
Change of control prior to clinical trial, time period of notice required to terminate (in days) 30 days    
Term of agreement following first commercial sale (in years) 10 years    
Intangible assets $ 255,300,000    
ENaC Inhibitors in CF | Parion Sciences, Inc      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]      
Collaborative arrangement development and regulatory potential milestone payments maximum 490,000,000    
Collaborative arrangement regulatory potential milestone payments maximum, global filling and approval 360,000,000    
Enac Inhibitors in Non Cf | Parion Sciences, Inc      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]      
Collaborative arrangement development and regulatory potential milestone payments maximum 370,000,000    
Additional Enac Inhibitors | Parion Sciences, Inc      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]      
Collaborative arrangement development and regulatory potential milestone payments maximum $ 230,000,000