<SEC-DOCUMENT>0000875320-16-000079-index.html : 20160503
<SEC-HEADER>0000875320-16-000079.hdr.sgml : 20160503
<ACCEPTANCE-DATETIME>20160503170633
ACCESSION NUMBER:		0000875320-16-000079
CONFORMED SUBMISSION TYPE:	S-3ASR
PUBLIC DOCUMENT COUNT:		6
FILED AS OF DATE:		20160503
DATE AS OF CHANGE:		20160503
EFFECTIVENESS DATE:		20160503

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			VERTEX PHARMACEUTICALS INC / MA
		CENTRAL INDEX KEY:			0000875320
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				043039129
		STATE OF INCORPORATION:			MA
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		S-3ASR
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-211096
		FILM NUMBER:		161616342

	BUSINESS ADDRESS:	
		STREET 1:		50 NORTHERN AVENUE
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02210
		BUSINESS PHONE:		6173416393

	MAIL ADDRESS:	
		STREET 1:		50 NORTHERN AVENUE
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02210
</SEC-HEADER>
<DOCUMENT>
<TYPE>S-3ASR
<SEQUENCE>1
<FILENAME>s-3april2016.htm
<DESCRIPTION>S-3ASR
<TEXT>
Document 1 - file: s-3april2016.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-4.2
<SEQUENCE>2
<FILENAME>exhibit_42xs-3xapril2016.htm
<DESCRIPTION>EXHIBIT 4.2
<TEXT>
Document 2 - file: exhibit_42xs-3xapril2016.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>3
<FILENAME>exhibit_51xs-3xapril2016.htm
<DESCRIPTION>EXHIBIT 5.1
<TEXT>
Document 3 - file: exhibit_51xs-3xapril2016.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-12.1
<SEQUENCE>4
<FILENAME>exhibit_121xs-3xapril2016.htm
<DESCRIPTION>EXHIBIT 12.1
<TEXT>
Document 4 - file: exhibit_121xs-3xapril2016.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.1
<SEQUENCE>5
<FILENAME>exhibit_231xs-3xapril2016.htm
<DESCRIPTION>EXHIBIT 23.1
<TEXT>
Document 5 - file: exhibit_231xs-3xapril2016.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>6
<FILENAME>image03a02.jpg
<TEXT>
Document 6 - file: image03a02.jpg

</DOCUMENT>
</SEC-DOCUMENT>