Stock-based Compensation Expense (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2016	Mar. 31, 2015
Stock-based compensation expense:
Less stock-based compensation expense capitalized to inventories	$ (845)	$ (884)
Total stock-based compensation included in costs and expenses	55,472	57,384
Stock options
Stock-based compensation expense:
Stock-based compensation expense by type of award:	26,260	28,959
Type of award:
Unrecognized Expense, Net of Estimated Forfeitures	$ 206,783
Weighted-average recognition period (in years)	2 years 9 months 29 days
Restricted stock and restricted stock units
Stock-based compensation expense:
Stock-based compensation expense by type of award:	$ 27,533	27,169
Type of award:
Unrecognized Expense, Net of Estimated Forfeitures	$ 223,184
Weighted-average recognition period (in years)	2 years 9 months 11 days
ESPP share issuances
Stock-based compensation expense:
Stock-based compensation expense by type of award:	$ 2,524	2,140
Type of award:
Unrecognized Expense, Net of Estimated Forfeitures	$ 3,143
Weighted-average recognition period (in years)	5 months 27 days
Research and development expenses
Stock-based compensation expense:
Total stock-based compensation included in costs and expenses	$ 34,448	38,217
Sales, general and administrative expenses
Stock-based compensation expense:
Total stock-based compensation included in costs and expenses	$ 21,024	$ 19,167