Intangible Assets and Goodwill (Details) - USD ($) $ in Thousands	1 Months Ended
	Oct. 31, 2014	Mar. 31, 2016	Dec. 31, 2015	Jun. 04, 2015	Dec. 31, 2014
Indefinite-Lived Intangible Assets [Line Items]
Intangible assets		$ 284,340	$ 284,340
Goodwill		50,384	50,384
Parion Sciences, Inc
Indefinite-Lived Intangible Assets [Line Items]
Intangible assets				$ 255,340
Goodwill				$ 10,468
BioAxone Biosciences Inc
Indefinite-Lived Intangible Assets [Line Items]
In-process research and development intangible asset					$ 29,000
Variable Interest Entity, Primary Beneficiary
Indefinite-Lived Intangible Assets [Line Items]
Intangible assets		284,340	284,340
Goodwill		$ 19,391	$ 19,391
Variable Interest Entity, Primary Beneficiary | BioAxone Biosciences Inc
Indefinite-Lived Intangible Assets [Line Items]
In-process research and development intangible asset	$ 29,000
Indefinite-lived Intangible Assets | Variable Interest Entity, Primary Beneficiary | Parion Sciences, Inc
Indefinite-Lived Intangible Assets [Line Items]
Fair value inputs, discount rate (percent)	7.10%
Indefinite-lived Intangible Assets | Variable Interest Entity, Primary Beneficiary | BioAxone Biosciences Inc
Indefinite-Lived Intangible Assets [Line Items]
Fair value inputs, discount rate (percent)	7.50%