Condensed Consolidated Statements of Operations (unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2016	Mar. 31, 2015
Revenues:
Product revenues, net	$ 394,410	$ 130,875
Royalty revenues	3,596	6,792
Collaborative revenues	74	842
Total revenues	398,080	138,509
Costs and expenses:
Cost of product revenues	49,789	9,381
Royalty expenses	860	2,926
Research and development expenses	255,860	215,599
Sales, general and administrative expenses	105,214	85,860
Restructuring expenses (income), net	687	(3,272)
Total costs and expenses	412,410	310,494
Loss from operations	(14,330)	(171,985)
Interest expense, net	(20,698)	(21,307)
Other income (expenses), net	4,411	(5,113)
Loss from continuing operations before provision for income taxes	(30,617)	(198,405)
Provision for income taxes	5,485	299
Net loss	(36,102)	(198,704)
(Income) loss attributable to noncontrolling interest	(5,529)	98
Net loss attributable to Vertex	$ (41,631)	$ (198,606)
Net loss:
Basic (usd per share)	$ (0.17)	$ (0.83)
Diluted (usd per share)	$ (0.17)	$ (0.83)
Shares used in per share calculations:
Basic (in shares)	243,831	239,493
Diluted (in shares)	243,831	239,493