Income Taxes - Narrative (Details) - USD ($)	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Tax Carryforwards
Unrealized gain	$ 1,088,000	$ 0
Federal statutory income tax rate (percent)	35.00%	35.00%	35.00%
Deferred tax liabilities recognized in other liabilities, excluding current portion	$ 110,439,000	$ 15,044,000
Unrecognized tax benefits	425,000	880,000	$ 2,024,000
Income tax penalties and interest accrued	0
Increase in valuation allowance	(306,400,000)
Estimated reduction in unrecognized tax benefits in next fiscal year	400,000
BioAxone Biosciences, Inc
Tax Carryforwards
Deferred tax liabilities recognized in other liabilities, excluding current portion	110,400,000	$ 11,500,000
State and Local Jurisdiction
Tax Carryforwards
Operating loss carryforwards	1,000,000,000
Tax credit carryforwards	97,300,000
Unrecognized tax benefits	195,100,000
Internal Revenue Service (IRS)
Tax Carryforwards
Operating loss carryforwards	4,200,000,000
Tax credit carryforwards	217,500,000
Operating loss carryforwards that will increase APIC when used to reduce income taxes payable	$ 1,100,000,000