Fair Value Measurements (Details) - USD ($) $ in Thousands	Dec. 31, 2015	Dec. 31, 2014
Level 1 \| Variable Interest Entity, Primary Beneficiary \| BioAxone Biosciences, Inc
Financial instruments carried at fair value (asset position):
Cash and cash equivalents	$ 75,100
Level 3
Financial instruments carried at fair value (asset position):
Fair value of the term loan	295,400
Recurring basis
Financial instruments carried at fair value (asset position):
Total financial assets	665,383	$ 1,054,389
Total financial liabilities	(901)
Recurring basis \| Money market funds
Financial instruments carried at fair value (asset position):
Cash equivalents:	199,507	290,531
Recurring basis \| Government-sponsored enterprise securities
Financial instruments carried at fair value (asset position):
Cash equivalents:	85,994
Marketable securities:	87,162	463,750
Recurring basis \| Commercial paper
Financial instruments carried at fair value (asset position):
Cash equivalents:	34,889
Marketable securities:	141,409	51,746
Recurring basis \| Corporate debt securities
Financial instruments carried at fair value (asset position):
Cash equivalents:	11,533
Marketable securities:	99,123	246,351
Recurring basis \| Prepaid and other current assets \| Foreign currency forward contracts
Financial instruments carried at fair value (asset position):
Prepaid and other current assets:	5,161	2,011
Recurring basis \| Other assets \| Foreign currency forward contracts
Financial instruments carried at fair value (asset position):
Other assets:	605
Recurring basis \| Other liabilities, current portion \| Foreign currency forward contracts
Financial instruments carried at fair value (asset position):
Other liabilities, current portion:	(769)
Recurring basis \| Other liabilities, excluding current portion \| Foreign currency forward contracts
Financial instruments carried at fair value (asset position):
Other liabilities, excluding current portion:	(132)
Recurring basis \| Level 1
Financial instruments carried at fair value (asset position):
Total financial assets	372,663	754,281
Total financial liabilities	0
Recurring basis \| Level 1 \| Money market funds
Financial instruments carried at fair value (asset position):
Cash equivalents:	199,507	290,531
Recurring basis \| Level 1 \| Government-sponsored enterprise securities
Financial instruments carried at fair value (asset position):
Cash equivalents:	85,994
Marketable securities:	87,162	463,750
Recurring basis \| Level 1 \| Commercial paper
Financial instruments carried at fair value (asset position):
Cash equivalents:	0
Marketable securities:	0	0
Recurring basis \| Level 1 \| Corporate debt securities
Financial instruments carried at fair value (asset position):
Cash equivalents:	0
Marketable securities:	0	0
Recurring basis \| Level 1 \| Prepaid and other current assets \| Foreign currency forward contracts
Financial instruments carried at fair value (asset position):
Prepaid and other current assets:	0	0
Recurring basis \| Level 1 \| Other assets \| Foreign currency forward contracts
Financial instruments carried at fair value (asset position):
Other assets:	0
Recurring basis \| Level 1 \| Other liabilities, current portion \| Foreign currency forward contracts
Financial instruments carried at fair value (asset position):
Other liabilities, current portion:	0
Recurring basis \| Level 1 \| Other liabilities, excluding current portion \| Foreign currency forward contracts
Financial instruments carried at fair value (asset position):
Other liabilities, excluding current portion:	0
Recurring basis \| Level 2
Financial instruments carried at fair value (asset position):
Total financial assets	292,720	300,108
Total financial liabilities	(901)
Recurring basis \| Level 2 \| Money market funds
Financial instruments carried at fair value (asset position):
Cash equivalents:	0	0
Recurring basis \| Level 2 \| Government-sponsored enterprise securities
Financial instruments carried at fair value (asset position):
Cash equivalents:	0
Marketable securities:	0	0
Recurring basis \| Level 2 \| Commercial paper
Financial instruments carried at fair value (asset position):
Cash equivalents:	34,889
Marketable securities:	141,409	51,746
Recurring basis \| Level 2 \| Corporate debt securities
Financial instruments carried at fair value (asset position):
Cash equivalents:	11,533
Marketable securities:	99,123	246,351
Recurring basis \| Level 2 \| Prepaid and other current assets \| Foreign currency forward contracts
Financial instruments carried at fair value (asset position):
Prepaid and other current assets:	5,161	2,011
Recurring basis \| Level 2 \| Other assets \| Foreign currency forward contracts
Financial instruments carried at fair value (asset position):
Other assets:	605
Recurring basis \| Level 2 \| Other liabilities, current portion \| Foreign currency forward contracts
Financial instruments carried at fair value (asset position):
Other liabilities, current portion:	(769)
Recurring basis \| Level 2 \| Other liabilities, excluding current portion \| Foreign currency forward contracts
Financial instruments carried at fair value (asset position):
Other liabilities, excluding current portion:	(132)
Recurring basis \| Level 3
Financial instruments carried at fair value (asset position):
Total financial assets	0	0
Total financial liabilities	0
Recurring basis \| Level 3 \| Money market funds
Financial instruments carried at fair value (asset position):
Cash equivalents:	0	0
Recurring basis \| Level 3 \| Government-sponsored enterprise securities
Financial instruments carried at fair value (asset position):
Cash equivalents:	0
Marketable securities:	0	0
Recurring basis \| Level 3 \| Commercial paper
Financial instruments carried at fair value (asset position):
Cash equivalents:	0
Marketable securities:	0	0
Recurring basis \| Level 3 \| Corporate debt securities
Financial instruments carried at fair value (asset position):
Cash equivalents:	0
Marketable securities:	0	0
Recurring basis \| Level 3 \| Prepaid and other current assets \| Foreign currency forward contracts
Financial instruments carried at fair value (asset position):
Prepaid and other current assets:	0	$ 0
Recurring basis \| Level 3 \| Other assets \| Foreign currency forward contracts
Financial instruments carried at fair value (asset position):
Other assets:	0
Recurring basis \| Level 3 \| Other liabilities, current portion \| Foreign currency forward contracts
Financial instruments carried at fair value (asset position):
Other liabilities, current portion:	0
Recurring basis \| Level 3 \| Other liabilities, excluding current portion \| Foreign currency forward contracts
Financial instruments carried at fair value (asset position):
Other liabilities, excluding current portion:	$ 0

Fair value portion of probable future economic benefits obtained or controlled by an entity as a result of past transactions or events.

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